• In the real world, retina specialists assess the pattern and amount of fluid – not just CST or vision thresholds – to decide whether retreatment is needed Traditional retreatment criteria in wAMD trials may not fully capture clinically meaningful retinal fluid 39 1 mm 2 Maybe? Conventional criteria • CST: 354 microns? • BCVA: loss of 5 letters from best prior BCVA? • Fluid assessment: evaluable area of 1 mm 2 Example A Example B Would you treat? 3 mm 2 Definitely Quantifying fluid volume provides a more complete view of disease activity BCVA: best corrected visual acuity