Glaucoma is an optic neuropathy driven by neuroinflammation — IOP reduction alone is insufficient 5 • Historically, glaucoma was thought to occur due to elevated IOP ‒ Raised IOP was thought to inflict damage on the ONH via mechanical stress ‒ Reduction of IOP is known to mitigate glaucoma progression • However, data suggest that an IOP - independent mechanism is at play ‒ Many people with high IOP do not develop glaucoma ‒ 30 - 40% of patients with glaucoma present with normal or low IOP. Many continue to experience vision loss due to glaucoma progression 1 • Current therapies focus on lowering IOP as it is the only modifiable risk factor • There is an unmet need to develop new therapies that target the underlying neuroinflammation that drives optic neuropathy Recent studies show that neuroinflammation is the key driver of optic neuropathy in glaucoma 2 1. Coyle S, et al. Targeting the NLRP3 Inflammasome in Glaucoma. Biomolecules. 2021 Aug 19;11(8):1239. doi : 10.3390/biom11081239. PMID: 34439904; PMCID: PMC8393362. 2. Adornetto et al. Neur Regen Res 19 Elevated IOP & Oxidative stress Neuroinflammation IOP: intraocular pressure; ONH: optic nerve head; RGC: retinal ganglion cell 1 2