Glaucoma is a group of progressive optic neuropathies characterized by retinal ganglion cell (RGC) degeneration and optic nerve (ON) damage • Glaucoma globally affects 3.5% of the population over 40 years old (76M WW, 3M US) • Cumulative incidence of blindness is 33% in 10 years 4 Lancet. 2011 Apr 16;377(9774):1367 - 77; Ophthalmology 2014 Nov;121(11):2081 - 90 RNFL: Retinal Nerve Fiber Layer Visual field Retina Nerve Fiber Layer OCT In the clinic, glaucoma progression is tracked using OCT (structural) and visual field (functional) measures Glaucoma ON Glaucoma is characterized by RGC degeneration and changes in the optic nerve head (its axons) Healthy ON