85 Kodiak Sciences Inc. Consolidated Statements of Operations and Comprehensive Loss (in thousands, except share and per share amounts) Year Ended December 31, 2022 2021 2020 Operating expenses Research and development ......................................................................... $ 267,591 $ 217,340 $ 107,389 General and administrative ......................................................................... 73,788 49,711 28,618 Total operating expenses ........................................................................ 341,379 267,051 136,007 Loss from operations...................................................................................... (341,379) (267,051) (136,007) Interest income.......................................................................................... 7,071 298 2,966 Interest expense......................................................................................... (18) (47) (25) Other income (expense), net ....................................................................... 503 (190) (30) Net loss......................................................................................................... $ (333,823) $ (266,990) $ (133,096) Net loss per common share, basic and diluted................................................... $ (6.39) $ (5.16) $ (2.91) Weighted-average shares of common stock outstanding used in computing net loss per common share, basic and diluted............................. 52,249,620 51,788,918 45,741,845 Other comprehensive income (loss) Change in unrealized gains (losses) related to available-for-sale debt securities, net of tax ......................................................................... (1,307) (53) 43 Total other comprehensive income (loss) ................................................. (1,307) (53) 43 Comprehensive loss ....................................................................................... $ (335,130) $ (267,043) $ (133,053) The accompanying notes are an integral part of these consolidated financial statements.