Adverse effects from today’s treatments for MESI often require multiple surgical interventions, but surgeries are complicated in MESI patients and require complete control of inflammation before, during and after each procedure Visual damage from glaucoma is irreversible and can lead to legal blindness Cataract repair in MESI patients is complex and can be contraindicated, leading to permanent vision loss RETISERT® (fluocinolone acetonide intravitreal implant) label: • 60% of patients will require chronic IOP lowering medications to control intraocular pressure • 37% will require filtering procedures to control intraocular pressure • Within an average post- implantation period of approximately 2 years, nearly all phakic eyes are expected to develop cataracts and require cataract surgery RETISERT® (fluocinolone acetonide intravitreal implant) Prescribing Information. • Concerns about permanent IOP elevation limit steroid use and dose • Supplemental topical drops to control elevated IOP are often insufficient, requiring invasive glaucoma surgeries • Once the optic nerve is damaged due to glaucoma (high eye pressure), the visual loss is irreversible • Even with good inflammation control, surgeries can trigger intractable inflammation, often leaving the eyes with no intraocular lens implant and/or suboptimal results ((synechiae/scarring) 48