My clinical experience: while topical steroids are the first line of therapy for MESI, only a third of patients achieve the treatment goal without the negative side effects 47 Sumit Sharma, MD ~1/3 Good responders Response to topical steroid treatment (diflupredprednate, Durezol) as first line of treatment in MESI patients ~1/3 Non responders and/or refractory ~1/3 Increased intraocular pressure ~2/3 of MESI patients require additional or alternative therapies after initial topical Durezol MESI patients