Biopolymer selection for glaucoma duet: choosing a biopolymer with similar size to that used in tarcocimab , demonstrating comparable ocular half - life and pharmacokinetics 29 0 2 0 4 0 6 0 1 0 1 1 0 2 1 0 3 1 0 4 1 0 5 1 0 6 O c u l a r P K o f T a r c o c i m a b i n R a b b i t s D a y s p o s t d o s i n g C o n c e n t r a t i o n o f t a r c o c i m a b ( n g / g ) A q u e o u s h u m o r C h o r o i d - R P E R e t i n a V i t r e o u s h u m o r 0 2 0 4 0 6 0 1 0 1 1 0 2 1 0 3 1 0 4 1 0 5 1 0 6 1 0 7 O c u l a r P K o f B i o p o l y m e r i n R a b b i t s D a y s p o s t d o s i n g C o n c e n t r a t i o n o f t a r c o c i m a b ( n g / g ) A q u e o u s h u m o r C h o r o i d - R P E R e t i n a V i t r e o u s h u m o r Biopolymer Alone Biopolymer + Antibody Biopolymer Tarcocimab 11.6 11.1* Rabbit Ocular H alf - Life Ocular PK of Biopolymer in Rabbits Ocular PK of Tarcocimab in Rabbits (Days) *Translates to a human ocular half - life mean of ~20 days