Location of inflammation Anterior Intermediate Posterior Panuveitis Day 1 Week 4 Effect of a single dose of KSI-101 After a single dose of KSI-101, heterogenous MESI diseases show rapid and meaningful responses to the simultaneous IL-6 and VEGF inhibition, irrespective of the location of the inflammation or the specific macular edema diagnosis Specific Macular Edema Etiology Idiopathic Juvenile Idiopathic Arthritis Focal Chorioretinal inflammation Punctate Inner Choroidopathy Post-Operative Macular Edema Day 1 Week 4 Effect of a single dose of KSI-101 11

The Retina Society 58th Annual Scientific Meeting - Page 12 The Retina Society 58th Annual Scientific Meeting Page 11 Page 13