What is macular edema secondary to inflammation (MESI)? Macular Edema with visual impairment Blood Retinal Barrier Disruption VEGF IL-6 IL-6 KSI-101 Common Clinical Presentation Common Pathophysiology Potential common therapy Angiogenesis Inflammation 5 MESI is a heterogenous group of diseases that clinically present with macular edema and visual impairment, which are caused by a common pathophysiology: inflammation and blood retinal barrier disruption