Tarcocimab demonstrated consistent 20-day ocular half-life across wet AMD, DME and RVO patients Height of the box represents the mean; error bars represent standard deviation. 20 All Wet AMD DME RVO 0 10 20 30 40 50 Acqueous humor t1/2 (days) n=47 n=23 DME n=8 n=16 Tarcocimab Human Ocular Half-Life by Indication RVO n=16 wAMD n=23 All n=47 T 1/2 tarcocimab 19.8 Days T 1/2 faricimab 7.5 Days