8 77 81 96 96 96 90 0 20 40 60 80 100 0 1 4 8 12 16 20 24 Pooled 5 mg and 10 mg Patients, % Weeks 54 69 92 92 100 100 100 0 20 40 60 80 100 0 1 4 8 12 16 20 24 Patients, % Weeks Proportion of patients in the 5 and 10 mg (pooled) dose level achieving absence of IRF 55 ≥90% of patients in the top two dose levels achieved and maintained absence of both intraretinal and subretinal fluid 26 26 26 26 25 24 21 Pooled 5 mg and 10 mg 26 26 26 26 25 24 21 Sample size Sample size Proportion of patients in the 5 and 10 mg (pooled) dose level achieving absence of SRF The APEX study is ongoing. Final results may be different due to additional data collection or data cleaning. Includes patients in the per protocol set that completed the Week 12 visit and met all the eligibility criteria. Excludes one patient in the 5 mg dose that discontinued treatment before Week 4, and one patient in the 10 mg dose with a significant epiretinal membrane at baseline (exclusion criterion). Includes all data available by the 29-Sep-25 reporting date. Preliminary Analysis New Data