Common Pathophysiology What is macular edema secondary to inflammation (MESI)? VEGF IL-6 IL-6 Blood Retinal Barrier Disruption Angiogenesis Inflammation 33 MESI is a heterogenous group of diseases that clinically present with macular edema and visual impairment, which are caused by a common pathophysiology: inflammation and blood retinal barrier disruption Macular edema with visual impairment Common Clinical Presentation Unifying Therapy? KSI-101