PEAK and PINNACLE master protocol design: a single screening process that enrolls distinct and complementary MESI patient populations Master Protocol Design: a single screening process for both studies CST≥320 and BCVA 25-78 letters Day 1 enroll in either study based on CST and BCVA Mild macular edema CST≥320 and <400 Moderate to severe macular edema CST ≥400 Moderate to severe vision impairment BCVA 25-70 Mild vision impairment BCVA 71-78 Mild to severe vision impairment BCVA 25-78 Moderate to severe edema with moderate to severe vision impairment PEAK PINNACLE Moderate to severe edema with good vision Mild edema with any vision impairment Two distinct and complementary sub-populations will be studied Both studies to run concurrently in all study sites Covers a wide spectrum of MESI patients 63