-2 -1 0 1 2 3 0 50 100 150 Log inhibitor [nM] % Control -2 0 2 4 0 50 100 150 Log inhibitor [pM] % Control KSI-101 is a potent dual inhibitor of VEGF signaling and IL-6 classic (cis) and soluble (trans) receptor-mediated pathways KSI-101 inhibits VEGF signaling KSI-101 inhibits soluble IL-6 receptor-mediated signaling KSI-101 inhibits IL-6 classic signaling 0 1 2 3 4 5 0 200000 400000 600000 800000 Log inhibitor [pM] RLUs KSI-101 IC50 = 164 pM Aflibercept IC50 = 130 pM IC50 = 77 pM IC50 = 2.3 nM 64