We have increased the size of the PEAK and PINNACLE pivotal program 92 PEAK PINNACLE n=300 n=300 Pivotal analysis 1 : 300 patients from PEAK (PEAK-1) Pivotal analysis 2 : 2 nd 300 patients from PEAK (PEAK-2) plus 300 patients from PINNACLE PEAK-1 PEAK-2 (or fewer depending on size of FDA-mandated safety database) n=300 4Q 2026 2Q 2027 • Patient enrollment faster than expected • No major changes to expected timelines are anticipated • Pivotal program aligned with FDA in type C meeting