The ABC Platform supports Kodiak’s science of immediacy and durability Designed-in Extended Tissue Residence Time A proprietary phosphorylcholine -based polymer is conjugated to an antibody to increase molecular size which extends ocular half-life High In-Vitro Potency Extended Ocular Half-Life in Animals Extended Ocular Half-Life in Humans Both unconjugated protein and conjugated protein demonstrate high binding affinity and potency in vitro 3x the ocular t½ of approved intravitreal biologics when measured in rabbits following an intravitreal injection 3x the ocular t½ of faricimab when measured from aqueous humor in patients following an intravitreal injection Powerful Immediacy via Unconjugated Antibody The unconjugated protein delivers a strong “pulse” of anti-VEGF inhibition during the loading phase, or to recapture control of the disease in patients whose disease has reactivated Extended Clinical Durability via Conjugated Antibody The conjugated protein maintains the signature durability as seen in Kodiak’s pivotal studies to date 17