Conjugates of Diverse APIs +/- a Biologic Target both intracellular and extracellular pathways High Drug Antibody Ratio (“DAR”) Can include APIs with DAR of 10 up to >250 Tailored Release of APIs Release of API payloads enabled by pH modulation or enzymatic cleavage of linkers Proven Safety Record of the ABC Platform >2,500 patient years of experience in patients Diverse APIs of varying biophysical properties including small molecules, macro- cycles, peptides and oligonucleotides are embedded in the biopolymer and released over a designed-in time Engineered to exhibit high binding affinity and specificity. Any biologic can be conjugated to the biopolymer Combines multiple APIs and can be tailored to meet a specific therapeutic goal. It is optically clear and made of phosphorylcholine, the primary hydrophilic component of human cell membranes Drug Cargo Antibody or Other Biologic Biopolymer A new combination of targeting, high drug loading, mixed API formats and tailored drug release – applications in ophthalmic and systemic diseases ANTIBODY BIOPOLYMER CONJUGATE DRUG (“ABCD”) Designed to embed small molecules and other Active Pharmaceutical Ingredients ("API") such as oligonucleotides and peptides into the biopolymer backbone for release over a designed-in time period A growing pipeline of multi-functional investigational therapies is built in modular fashion on our ABC ® Platform and is maturing rapidly 7 1 2 3 4