PINNACLE 97 PEAK and PINNACLE – Key question: why are the key secondary endpoints different between PEAK and PINNACLE? PEAK The Key Secondary Endpoints are tailored specifically to the patient population included in their respective study Day 1 BCVA 75 CST 517 Week 4 BCVA +19 CST -234 Day 1 BCVA 67 CST 360 Week 4 BCVA +6 CST -81 Day 1 BCVA 54 CST 512 Week 4 BCVA +19 CST -234 Patient Population Treatment Objective Key Secondary Endpoint Moderate to severe edema with moderate to severe vision impairment Mild edema with any vision impairment Moderate to severe edema with good vision Macular edema resolution and vision improvement Macular edema resolution and vision maintenance Macular edema resolution and vision improvement Proportion of ≥15 letter improvement Proportion of ≥15 letter loss prevention Proportion of ≥15 letter improvement APEX Case Examples