7 4 Kodiak’s multi-asset pipeline in GA is designed to address the multifactorial nature of the disease Human Genetics Complement Smoking Age Diabetes Advanced AMD/GA Inflammation NLRP3 inflammasome, IL- 1 β, IL-6 Hypoxia, lipid metabolism VEGF Inhibitors of NLRP3 and Complement IL-6 + complement VEGF + complement